The product of ITGAV belongs to the integrin alpha chain family.
Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling.
The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit.
This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits.
The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor.
This integrin may regulate angiogenesis and cancer progression.
Alternative splicing results in multiple transcript variants.
Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:10,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human Cleaved-Integrin alphaV HC (K889).
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa810-890 from human Integrin alphaV HC at C-terminal.
