The protein encoded by IL19 is a cytokine that belongs to the IL10 cytokine subfamily.
This cytokine is found to be preferentially expressed in monocytes.
It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3).
A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses.
Alternatively spliced transcript variants encoding the distinct isoforms have been described.
IL19 (Interleukin 19) is a protein coding gene.
Diseases associated with IL19 include spongiotic dermatitis and psoriasis.
Among its related pathways are Akt signaling and PEDF induced signaling.
Applications:Suitable for use in Western Blot, Immunohistochemistry (paraffin), ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry (paraffin): 1:500-1:200ELISA: 1:10,000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human IL-19. Species Crossreactivity: rat
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu Rt
Immunogen：Synthetic peptide corresponding to aa51-100 from the internal region of human IL-19.
