84-5495-08　［取扱停止］IL-10R alpha 30ul　537828

特徴

• Interleukin-10 receptor subunit alpha encoded by IL10RA is a receptor for interleukin 10.
• Interleukin-10 receptor subunit alpha is structurally related to interferon receptors.
• It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines.
• This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway.
• Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.
• Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
• Applications:Suitable for use in Western Blot, Immunofluorescence, and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunofluorescence: 1:200-1:1000ELISA: 1:10,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.