84-5493-89　［取扱停止］IGFN1 100ul　537763

特徴

• IGFN1 (immunoglobulin-like and fibronectin type III domain containing 1) is an 868aa protein that is encoded by a gene located on chromosome 1.
• Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome.
• There are about 3000 genes on chromosome 1, many of which are associated with a large number of diseases.
• Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A.
• When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs.
• The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration.
• The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis.
• Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.
• A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia.
• Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.
• Applications:Suitable for use in Western Blot, Immunohistochemistry..
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:2000-1:5000Immunohistochemistry (paraffin): 1:200-1:500Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.