IFNB1 encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens.
The protein encoded by IFNB1 belongs to the type I class of interferons, which are important for defense against viral infections.
In addition, type I interferons are involved in cell differentiation and anti-tumor defenses.
Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines.
Overactivation of type I interferon secretion is linked to autoimmune diseases.
Mice deficient for IFNB1 display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection.
Applications:Suitable for use in Immunohistochemistry (paraffin), ELISA.
Other
Recommended Dilution:Immunohistochemistry: (paraffin) 1:50-1:200ELISA: 1:10,000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human IFN-beta.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa91-140 from human IFN-beta.
