This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets.
The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions.
Histidine rich glycoprotein also has a peptide that displays antimicrobial activity against C.
albicans, E.
coli, S.
aureus, P.
aeruginosa, and E.
faecalis.
It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen.
Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect.
Mutations in HRG lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human HRG. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human HRG protein.
