At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane.
The chromobox 3 encoded by CBX3 binds DNA and is a component of heterochromatin.
This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane.
The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane.
This protein binds histone H3 tails methylated at Lys-9 sites.
This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks.
Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
Applications:Suitable for use in Western Blot, Immunohistochemistry, and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry (paraffin): 1:100-1:300ELISA: 1:40,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human HP1gamma. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human HP1gamma around the non-phosphorylation site of S93.
