84-5482-80 ［取扱停止］HDAC4 30ul 537142
特徴
- Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events.
- Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.
- Histone deacetylase 4 encoded by HDAC4 belongs to class II of the histone deacetylase/acuc/apha family.
- It possesses histone deacetylase activity and represses transcription when tethered to a promoter.
- Histone deacetylase 4 does not bind DNA directly, but through transcription factors MEF2C and MEF2D.
- It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
- Applications:Suitable for use in Western Blot and ELISA.
- Other applications not tested.
- Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:20,000Optimal dilutions to be determined by the researcher.
- Storage and Stability:May be stored at 4°C for short-term only.
- Aliquot to avoid repeated freezing and thawing.
- Store at -20°C.
- Aliquots are stable for 12 months after receipt.
- For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
- Size：30ul
- Host：rabbit
- Source Antibody：human
- Grade：Affinity Purified
- Purity：Purified by immunoaffinity chromatography.
- Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
- Specificity：Recognizes endogenous levels of human HDAC4. Species Crossreactivity: mouse, rat
- Isotype：IgG
- Calc Applications Abbrev：E WB
- Calc Crossreactivity：Hu Mo Rt
- Immunogen：Synthetic peptide corresponding to human HDAC4 around the non-phosphorylation site of S632.
- Swiss Prot Number：P56524
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