HMG-Box Transcription Factor 1 is a transcriptional repressor that binds to the promoter region of target genes.
Plays a role in the regulation of the cell cycle and of the Wnt pathway.
Binds preferentially to the sequence 5-TTCATTCATTCA-3.
Binding to the H1F0 promoter is enhanced by interaction with RB1.
Disrupts the interaction between DNA and TCF4.
Among its related pathways are C-MYC pathway and Regulation of Wnt-mediated beta catenin signaling and target gene transcription.
Gene Ontology (GO) annotations related to this gene include RNA binding.
Applications:Suitable for use in Western Blot, Immunohistochemistry, and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry (paraffin): 1:100-1:300ELISA: 1:10,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human HBP1. Species Crossreactivity: mouse, rat, monkey
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu Mk Mo Rt
Immunogen：Synthetic peptide corresponding to aa400-480 of human HBP1 at C-terminal.
