84-5482-22　［取扱停止］HBEGF 30ul　537112

特徴

• HBEGF (heparin binding EGF like growth factor) is a protein coding gene.
• Diseases associated with HBEGF include diphtheria and bladder disease.
• Among its related pathways are RET signaling and p70S6K signaling.
• GO annotations related to this gene include growth factor activity and epidermal growth factor receptor binding.
• An important paralog of this gene is AREG.
• Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4.
• Required for normal cardiac valve formation and normal heart function.
• Promotes smooth muscle cell proliferation.
• May be involved in macrophage-mediated cellular proliferation.
• It is mitogenic for fibroblasts, but not endothelial cells.
• It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF.
• Also acts as a diphtheria toxin receptor.
• Applications:Suitable for use in Western Blot and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.