Glycogen synthase kinase 3 beta encoded by GSK3B is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily.
It is involved in energy metabolism, neuronal cell development, and body pattern formation.
Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of GSK3B may be relevant to the pathogenesis of Alzheimer disease.
Alternatively spliced transcript variants encoding different isoforms have been found for GSK3B.
Applications:Suitable for use in Western Blot, Immunofluorescence, Immunohistochemistry, ELISA, and Immunoprecipitation.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunofluorescence: 1:50-1:200Immunohistochemistry (paraffin): 1:100-1:300ELISA: 1:5000Immunoprecipitation (lysate): 2-5ug/mgOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human GSK3β protein only when phosphorylated at S9. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E IF IHC IP WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide derived from human GSK3 beta around the phosphorylation site of S9.
