Along with the other previously "orphan" receptors GPR55 and GPR119, G Protein-Coupled Receptor 18 has been found to be a receptor for endogenous lipid neurotransmitters, several of which also bind to cannabinoid receptors.
Protein-Coupled Receptor 18 is a receptor for N-arachidonyl glycine.
The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
May contribute to regulation of the immune system.
Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors.
Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity.
An important paralog of this gene is GPR20.
Applications:Suitable for use in Western Blot, Immunofluorescence, and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunofluorescence: 1:200-1:1000ELISA: 1:40,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human GPR18.
Isotype：IgG
Calc Applications Abbrev：E IF WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa100-180 of human GPR18.
