84-5476-39　［取扱停止］GNA11 100ul　536797

特徴

• The protein encoded by GNA11 belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems.
• G proteins are composed of 3 units: alpha, beta and gamma.
• This gene encodes one of the alpha subunits (subunit alpha-11).
• Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2).
• Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations.
• GNA11 (G protein subunit alpha 11) is a protein coding gene.
• Diseases associated with GNA11 include hypocalciuric hypercalcemia, Type Ii and hypocalcemia, autosomal dominant 2.
• Among its related pathways are calcium signaling pathway and ADP signalling through P2Y purinoceptor 1.
• GNA11 (G protein subunit alpha 11) is a protein coding gene.
• Diseases associated with GNA11 include hypocalciuric hypercalcemia, Type Ii and hypocalcemia, autosomal dominant 2.
• Among its related pathways are calcium signaling pathway and ADP signalling through P2Y purinoceptor 1.
• Applications:Suitable for use in Western Blot and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.