This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily.
This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.
This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A.
The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor.
This gene is intronless.
Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
[provided by RefSeq, Jul 2008]ADRB2 (Adrenoceptor Beta 2) is a Protein Coding gene.
Diseases associated with ADRB2 include obesity and asthma.
Among its related pathways are Signaling by GPCR and cAMP signaling pathway.
GO annotations related to this gene include G-protein coupled receptor activity and enzyme binding.
An important paralog of this gene is TAAR9.
eta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.
The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
he adrenergic beta2 receptor (beta2-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta1 and beta3.
They are located primarily in the CNS, heart, kidney and muscle.
Applications:Suitable for use in Western Blot, Immunohistochemistry, and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry (paraffin): 1:100-1:300ELISA: 1:40,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human Gab 2/4.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa40-120 of human Gab 2/4 at N-terminal.
