FK506 Binding Protein 1B encoded by FKBP1B is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking.
This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin.
It is highly similar to the FK506-binding protein 1A.
Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle.
There are two alternatively spliced transcript variants of this gene encoding different isoforms.
FKBP1B (FK506 binding protein 1B) is a protein coding gene.
Diseases associated with FKBP1B include catecholaminergic polymorphic ventricular tachycardia and heart disease.
Among its related pathways are antiarrhythmic pathway, pharmacodynamics and transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human FKB1B. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human FKB1B protein.
