FHL2 encodes a member of the four-and-a-half-LIM-only protein family.
Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger.
This protein is thought to have a role in the assembly of extracellular membranes.
Also, FHL2 is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway.
Multiple alternatively spliced variants encoding different isoforms have been identified.
FHL2 (four and a half LIM domains 2) is a protein coding gene.
Diseases associated with FHL2 include familial Iiolated dilated cardiomyopathy and rhabdomyosarcoma.
Among its related pathways are metabolism and signaling events mediated by HDAC class III.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Westrn Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human FHL2. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human FHL2 protein.
