Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix.
Calcium-binding is apparently required to mediate its binding to laminin and nidogen.
It mediates platelet adhesion via binding fibrinogen.
Four splice variants which differ in the 3' end have been identified.
Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants.
FBLN1 (fibulin 1) is a protein coding gene.
Diseases associated with FBLN1 include synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses and fbln1-related developmental delay-central nervous system anomaly-syndactyly syndrome.
Among its related pathways are elastic fiber formation and cell adhesion_cell-matrix glycoconjugates.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human FBLN1. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to human FBLN1.
