FAT1 is an ortholog of the drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during drosophila development.
FAT1 product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats.
In addition to containing 34 tandem cadherin-type repeats, FAT1 product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain.
FAT1 is expressed at high levels in a number of fetal epithelia.
Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication.
Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (paraffin): 1:50-1:300Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human FAT1.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa1140-1220 of human FAT1.
