FASLG is a member of the tumor necrosis factor superfamily.
The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS.
The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death.
It has also been implicated in the progression of several cancers.
Defects in FASLG may be related to some cases of systemic lupus erythematosus (SLE).
Alternatively spliced transcript variants have been described.
FASLG (fas ligand) is a protein coding gene.
Diseases associated with FASLG include autoimmune lymphoproliferative syndrome and faslg-related autoimmune lymphoproliferative syndrome.
Among its related pathways are allograft rejection and Akt signaling.
Applications:Suitable for use in Immunohistochemistry and ELISA.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (paraffin): 1:50-1:200ELISA: 1:10,000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human FAS-L
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa121-170 of human FAS-L.
