DNA2 (DNA replication helicase/nuclease 2) is a protein coding gene.
Diseases associated with DNA2 include progressive external ophthalmoplegia with mitochondrial Dna deletions, autosomal dominant 6 and Seckel syndrome 8.
Among its related pathways are DNA double-strand break repair and telomere C-strand (lagging strand) synthesis.
DNA2 encodes a member of the DNA2/NAM7 helicase family.
The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability.
Mutations in DNA2 are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8.
Alternatively spliced transcript variants have been found for DNA2.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human DNA2. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to human DNA2 protein.
