DDR2 (discoidin domain receptor tyrosine kinase 2) is a protein coding gene.
Diseases associated with DDR2 include spondylometaepiphyseal dysplasia, short limb-hand type and squamous cell carcinoma.
Among its related pathways are Akt signaling and Nanog in mammalian ESC pluripotency.
DDR2 encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family.
RTKs play a key role in the communication of cells with their microenvironment.
The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling.
This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness.
Mutations in DDR2 are the cause of short limb-hand type spondylometaepiphyseal dysplasia.
Applications:Suitable for use in Immunohistochemistry, ELISA.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (paraffin): 1:50-1:200ELISA: 1:10,000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human DDR2. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to aa31-80 of human DDR2.
