84-5443-01　［取扱停止］COX4 (Cytochrome C Oxidase Subunit 4, COXIV) 30ul　535032

特徴

• Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain.
• It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane.
• The complex consists of 13 mitochondrial- and nuclear-encoded subunits.
• The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities.
• The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex.
• COX4I1 (cytochrome c oxidase subunit 4I1) encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme.
• It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it.
• Pseudogenes related to COX4I1 are located on chromosomes 13 and 14.
• Alternative splicing results in multiple transcript variants encoding different isoforms.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:1000Immunohistochemistry (paraffin): 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.