COL27A1 encodes a member of the fibrillar collagen family, and plays a role during the calcification of cartilage and the transition of cartilage to bone.
The encoded protein product is a preproprotein.
It includes an N-terminal signal peptide, which is followed by an N-terminal propetide, mature peptide and a C-terminal propeptide.
The N-terminal propeptide contains thrombospondin N-terminal-like and laminin G-like domains.
The mature peptide is a major triple-helical region.
The C-terminal propeptide, also known as COLFI domain, plays crucial roles in tissue growth and repair.
Mutations in COL27A1 cause Steel syndrome.
Alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been determined.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human CORA1. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa1551-1600 of human CORA1.
