COL17A1 (collagen type XVII alpha 1 chain) encodes the alpha chain of type XVII collagen.
Unlike most collagens, collagen XVII is a transmembrane protein.
Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane.
Mutations in COL17A1 are associated with both generalized atrophic benign and junctional epidermolysis bullosa.
Two homotrimeric forms of type XVII collagen exist.
The full length form is the transmembrane protein.
A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:10,000ELISA: 1:10,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous COL17A1.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa481-530 from human COL17A1.
