84-5438-06　［取扱停止］CKR-5 30ul　534754

特徴

• CCR5 encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors.
• This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells.
• Defective alleles of CCR5 have been associated with the HIV infection resistance.
• The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES).
• Expression of CCR5 was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation.
• CCR5 is located at the chemokine receptor gene cluster region.
• An allelic polymorphism in CCR5 results in both functional and non-functional alleles; the reference genome represents the functional allele.
• Two transcript variants encoding the same protein have been found for CCR5.
• Applications:Suitable for use in Western Blot, Immunohistochemistry (paraffin), ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry (paraffin): 1:500-1:200ELISA: 1:10,000-1:20,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.