CHRD encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes.
The encoded protein may also have roles in organogenesis and during adulthood.
It has been suggested that CHRD could be a candidate gene for Cornelia de Lange syndrome.
Reduced expression of CHRD results in enhanced bone regeneration.
Alternative splicing results in multiple transcript variants.
Other alternative splice variants have been described but their full length sequence has not been determined.
CHRD (chordin) is a protein coding gene.
Diseases associated with CHRD include Cornelia De Lange syndrome.
Among its related pathways are mesodermal commitment pathway and signaling by BMP.
Applications:Suitable for use in Immunohistochemistry (paraffin), ELISA.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (paraffin): 1:50-1:300ELISA: 1:10,000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human Chordin. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa905-954 from human Chordin.
