84-5436-32　［取扱停止］CHD1L 100ul　534660

特徴

• CHD1L encodes a DNA helicase protein involved in DNA repair.
• The chromodomain-helicase-DNA-binding protein 1-like converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage.
• Several alternatively spliced transcripts variants have been described for this gene.
• CHD1L (Chromodomain Helicase DNA Binding Protein 1-Like) is a Protein Coding gene.
• Diseases associated with CHD1L include fibrosarcoma of bone.
• Among its related pathways are Chromatin Regulation / Acetylation and DNA Double-Strand Break Repair.
• Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity.
• DNA helicase which plays a role in chromatin-remodeling following DNA damage.
• Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair.
• Able to catalyze nucleosome sliding in an ATP-dependent manner.
• Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding.
• Applications:Suitable for use in Western Blot and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:20,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.