Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks).
Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression.
Another family of proteins, Cdk inhibitors, also plays a role in regulating the cell cycle by binding to cyclin-Cdk complexes and modulating their activity.
Cdks are considered potential targets for anti-cancer therapy due to their involvement with cell cycle regulation.
Cdks are also involved in the regulation of transcription and mRNA processing.
CdkL4 (cyclin-dependent kinase-like 4) is a 315aa protein that belongs to the CMGC Ser/Thr protein kinase family and may be involved in cell cycle regulation.
Applications:Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry (paraffin): 1:100-1:300Immunofluorescence: 1:200-1:1000ELISA: 1:40,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human CdkL4.
Isotype：IgG
Calc Applications Abbrev：E IF IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa240-320 of human CdkL4 at C-terminal.
