The protein encoded by CD27 (CD27 molecule) is a member of the TNF-receptor superfamily.
This receptor is required for generation and long-term maintenance of T cell immunity.
It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis.
This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK.
Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor.
CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
CD27 is a protein coding gene.
Diseases associated with CD27 include lymphoproliferative syndrome 2 and autosomal recessive lymphoproliferative disease.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human CD27.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa1-80 from human CD27.
