The peptidase M14 family of carboxypeptidases (CPs) are involved in various functions throughout the body which include digestion of food and biosynthesis of peptides that function in intercellular signaling.
CCP2 (cytosolic carboxypeptidase 2), also known as AGBL2 (ATP/GTP binding protein-like 2), is a 902aa cytoplasmic protein belonging to the peptidase M14 family.
CCP2 is considered a metallocarboxypeptidase that may play a role in the processing of tubulin.
CCP2 binds one zinc ion per subunit as a cofactor and exists as three alternatively spliced isoforms.
The gene encoding CCP2 is located on human chromosome 11p11.2.
Chromosome 11 houses over 1400 genes and comprises nearly 4% of the human genome.
Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.
Applications:Suitable for use in Western Blot, Immunohistochemistry, and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry (paraffin): 1:100-1:300ELISA: 1:40,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human CCP2. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to aa700-780 of human CCP2 at C-terminal.
