84-5426-67　［取扱停止］CCAR1 100ul　534161

特徴

• Associates with components of the mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter.
• Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone.
• Also functions as a p53 coactivator.
• May thus play an important role in transcriptional regulation.
• May be involved in apoptosis signaling in the presence of the reinoid CD437.
• Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A.
• Plays a role in cell cycle progression and/or cell proliferation.
• In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells.
• Can act as a both a coactivator and corepressor of AR-mediated transcription.
• Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites.
• May play an important role in the growth and tumorigenesis of prostate cancer cells.
• Applications:Suitable for use in Western Blot and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.