Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization.
CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2) encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex.
The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma.
The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics.
The subunit encoded by CACNA2D2 undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide.
This subunit is a receptor for the antiepileptic drug, gabapentin.
Mutations in CACNA2D2 are associated with early infantile epileptic encephalopathy.
Single nucleotide polymorphisms in CACNA2D2 are correlated with increased sensitivity to opioid drugs.
Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes CaVCaV alpha2 delta2.. Species Crossreactivity: Human, Mouse, Rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to CaV alpha2 delta2.
