CASP2 (caspase 2) encodes a member of the cysteine-aspartic acid protease (caspase) family.
Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates.
The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis.
Increased expression of CASP2 may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for CASP2.
Applications:Suitable for use in Immunohistochemistry and ELISA.
Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 1:100-1:300ELISA: 1:10,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human Caspase-2 protein only when phosphorylated at S157.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to human Caspase-2 around the phosphorylation site of S157
