84-5421-53　［取扱停止］CACB4 30ul　533886

特徴

• CACNB4 (calcium voltage-gated channel auxiliary subunit beta 4) is a protein coding gene.
• Diseases associated with CACNB4 include episodic ataxia, type 5 and epilepsy, idiopathic generalized 9.
• Among its related pathways are arrhythmogenic right ventricular cardiomyopathy (ARVC) and Fc-GammaR pathway.
• CACNB4 encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins.
• Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1 ratio.
• Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing.
• The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation.
• Certain mutations in CACNB4 have been associated with idiopathic generalized epilepsy (IGE), juvenile myoclonic epilepsy (JME), and episodic ataxia, type 5.
• Applications:Suitable for use in Western Blot and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.