84-5416-23　［取扱停止］BinCARD 30ul　533618

特徴

• BinCARD (Bcl10-interacting CARD protein) is a 228aa protein that exists as two alternatively spiced isoforms.
• BinCARD localizes to nucleus and is expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart, liver, thymus and brain.
• Containing a CARD domain, BinCARD plays a role in inhibiting the effects of Bcl10-induced activation of NFkappaB possibly by inhibiting the phosphorylation of Bcl10 in a CARD-dependent manner.
• The BinCARD gene maps to chromosome 9q22.1.
• Chromosome 9 consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes.
• Notably, chromosome 9 encompasses the largest interferon family gene cluster.
• Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype.
• Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG.
• Familial dysautonomia is also associated with chromosome 9 though through the gene IKAP.
• Applications:Suitable for use in Immunohistochemistry, ELISA.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry (paraffin): 1:100-1:300ELISA: 1:40,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.