BCL2L2 encodes a member (BCL2 like 2) of the BCL-2 protein family.
The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators.
Expression of BCL2L2 in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions.
Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons.
Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis.
Alternative splicing results in multiple transcript variants.
Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly (A) binding protein, nuclear 1) gene.
Applications:Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry (paraffin): 1:100-1:300Immunofluorescence: 1:200-1:1000ELISA: 1:10,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human Bcl-w. Species Crossreactivity: mouse, rat
Isotype：IgG
Calc Applications Abbrev：E IF IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa100-180 of human Bcl-w at C-terminal.
