84-5414-82　［取扱停止］BCAS3 100ul　533511

特徴

• Rudhira/BCAS3 (breast cancer amplified sequence 3) is a conserved protein expressed in the embryonic vasculature and malignant tumors.
• Rudhira is a predicted WD40 domain protein.
• During mouse development Rudhira is expressed in erythropoietic and angiogenic precursors but not in their differentiated progeny.
• This transient expression of Rudhira is also seen in normal adult angiogenesis.
• BCAS3, the human ortholog of Rudhira is 98% identical and the gene maps to a breakpoint of hematological neoplasms on chromosome 17q23.
• BCAS3 is also expressed in vascular development in embryoid bodies in vitro and was originally identified as a gene over-expressed in breast cancers.
• It is reported to be a target of metastasis associated protein-1 (MTA-1).
• Further BCAS3 expression is also upregulated in grade III and IV glioblastomas where it is misexpressed in the tumor cells.
• Applications:Suitable for use in Western Blot and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.