ASPM is the human ortholog of the drosophila melanogaster ‘abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts.
Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis.
Mutations in this gene are associated with microcephaly primary type 5.
Multiple transcript variants encoding different isoforms have been found for this gene.
ASPM (abnormal spindle microtubule assembly) is a protein coding gene.
Diseases associated with ASPM include microcephaly 5, primary, autosomal recessive and primary microcephaly.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (paraffin): 1:50-1:300Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human ASPM.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa1230-1310 from human ASPM.
