84-5410-53　［取扱停止］ASCL1 30ul　533289

特徴

• ASCL1 encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors.
• The protein activates transcription by binding to the E box (5'-CANNTG-3').
• Dimerization with other BHLH proteins is required for efficient DNA binding.
• This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons.
• Mutations in ASCL1 may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.
• ASCL1 (Achaete-Scute Family BHLH Transcription Factor 1) is a Protein Coding gene.
• Diseases associated with ASCL1 include central hypoventilation syndrome, congenital and differentiating neuroblastoma.
• Among its related pathways are dopaminergic neurogenesis and notch-mediated HES/HEY network.
• Applications:Suitable for use in Immunohistochemistry and ELISA.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry (paraffin): 1:50-1:200ELISA: 1:10,000-1:20,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.