84-5407-03　［取扱停止］APBB1 100ul　533113

特徴

• APBB1 (amyloid beta precursor protein binding family B member 1) is a protein coding gene.
• Diseases associated with APBB1 include Alzheimer disease and second-degree atrioventricular block.
• Among its related pathways are DNA double strand break response and respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
• The protein encoded by APBB1 is a member of the Fe65 protein family.
• It is an adaptor protein localized in the nucleus.
• It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein.
• APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation.
• This encoded protein could play an important role in the pathogenesis of Alzheimer's disease.
• It is thought to regulate transcription.
• Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression.
• Multiple alternatively spliced transcript variants encoding different isoforms have been described for APBB1.
• Applications:Suitable for use in Western Blot and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.