ADAMTS2 (ADAM metallopeptidase with thrombospondin type 1 motif 2) encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family.
Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif.
Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains.
The encoded preproprotein is proteolytically processed to generate the mature procollagen N-proteinase.
This proteinase excises the N-propeptide of the fibrillar procollagens types I-III and type V.
Mutations in ADAMTS2 cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder.
Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:10,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human ADAMTS-2.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa1140-1220 from human ADAMTS-2 at C-terminal.
