ABCC12 is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein (ATP binding cassette subfamily C member 12) contains two ATP-binding domains and 12 transmembrane regions.
ABC proteins transport various molecules across extra- and intracellular membranes.ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White.
ABCC12 is a member of the MRP subfamily which is involved in multi-drug resistance.
ABCC12 and another subfamily member are arranged head-to-tail on chromosome 16q12.1.
Increased expression of ABCC12 is associated with breast cancer.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：30ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human ABCC12.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa730-810 of human ABCC12.
