HAAO (3-hydroxyanthranilate 3,4-dioxygenase) is a protein coding gene.
Among its related pathways are metabolism and superpathway of tryptophan utilization.
3-hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron.
It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system.
HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid.
QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors.
Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders.
HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:5000-1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human 3HAO. Species Crossreactivity: Mouse, Rat
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa30-110 from human 3HAO.
