This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression.
The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia.
The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene.
This gene is also a putative breast tumor suppressor.
Alternative splicing results in transcript variants.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilutions:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.