84-5313-52　TAOK2 200ul　528865

特徴

• Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation.
• This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminal truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway.
• Isoform 1, but not isoform 2, activates the JNK MAP kinase pathway through the specific activation of the upstream MKK3 and MKK6 kinases.
• Isoform 1 binds to microtubules and affects their organization and stabilityindependently of its kinase activity.
• Prevents MAP3K7-mediated activation of IKKA, and thus NF-kappa-B activation, but not that of JNK.
• Phosphorylates itself, MBP, activated MAPK8 and tubulins.
• May play a role in the osmotic stress-MAPK8 pathway.
• Isoform 2, but not isoform 1, isrequired for PCDH8 endocytosis.
• Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2.
• This process leads to PCDH8 endocytosis and CDH2 cointernalization (By similarity).
• Both isoforms are involved in MAPK14 phosphorylation.
• Applications:Suitable for use in Western Blot and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000ELISA (peptide): 1:20,000-1:40,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.