Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling.
Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system.
Regulates dendrite and axon branching and morphogenesis.
Promotes the migration of cerebellar granule cells and of endothelial cells.
Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro).
Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade.
Interaction with PLXNB1 mediates activation of RHOA.
Applications:Suitable for use in Western Blot, Immunohistochemistry and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:1000-3000Immunohistochemistry: 1:200ELISA (peptide): 1:20,000-1:40,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography from serum.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of total human SEMA4D.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to human SEMA4D at C-terminal. Species sequence homology: porcine (91%), sheep (91%), rabbit (100%), canine (91%)
