84-5272-59　PATE3 100ul　526729

特徴

• PATE3 (prostate and testis expressed protein 3), also known as PATE-DJ or HEL-127, is a 98aa protein that contains one UPAR/Ly6 domain and belongs to the PATE family.
• PATE3 is a secreted protein that is expressed in prostate and testis.
• The gene that encodes PATE3 consists of around 3,490 bases and maps to human chromosome 11p15.5.
• Chromosome 11, which comprises approximately 4% of the human genome, is considered a gene and disease association-dense chromosome.
• The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks.
• Atm mutation leads to the disorder known as ataxia- telangiectasia.
• The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene.
• Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes.
• Applications:Suitable for use in Western Blot, Immunohistochemistry and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000, incubate membrane with diluted primary antibody in TBS, 5% milk, 0.1% Tween 20 at 4°C with gentle shaking, overnight
• Immunohistochemistry: 1:50-1:200ELISA (peptide): 1:20,000-1:40,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.