84-5260-21　NR1H3 100ul　526105

特徴

• The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily.
• The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation.
• This protein is highly expressed in visceral organs, including liver, kidney and intestine.
• It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements.
• Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis.
• Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Applications:Suitable for use in Western Blot, Immunohistochemistry and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000, incubate membrane with diluted primary antibody in TBS, 5% milk, 0.1% Tween 20 at 4°C with gentle shaking, overnight
• Immunohistochemistry: 1:50-1:200ELISA (peptide): 1:20,000-1:40,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.