84-5258-41　NLGN2 100ul　526014

特徴

• Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members.
• Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells.
• Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors).
• Functions by recruiting and clustering synaptic proteins.
• Promotes clustering of postsynaptic GABRG2 and GPHN.
• Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing.
• Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency.
• May promote the initial formation of synapses, but is not essential for this.
• In vitro, triggers the de novo formation of presynaptic structures.
• Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity).
• Applications:Suitable for use in Western Blot and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:1000-1:3000, incubate membrane with diluted antibody in TBS, 5% milk, 0.1% Tween20 at 4°C with gentle shaking, overnight
• ELISA (peptide): 1:20,000-1:40,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.