84-5241-63　MAOA 200ul　525119

特徴

• Monoamine oxidase (MAO) is an enzyme of the mitochondrial outer membrane and catalyzes the oxidative deamination of biogenic amines throughout the body (1).
• MAO is critical in the neuronal metabolism of catecholamine and indolamine transmitters (2).
• Cultured skin fibroblasts show both MAO-A and MAO-B and both MAOs differ in molecular structure (1).
• MAO-A, the primary type in fibroblasts, preferentially degrades serotonin and norepinephrine (3).
• Only MAO-B is present in platelets and only MAO-A is present in trophoblasts (1).
• MAO-B, the primary type found not only in platelets but also in the brain of man and other primates, preferentially degrades phenylethylamine and benzylamine (3).
• MAO has been of particular interest to psychiatry and genetics because of the suggestion that low activity is a ‘genetic marker’ for schizophrenia (4).
• The genes which encode MAO-A and MAO- B map to human chromosome Xp11.23 (5).
• Applications:Suitable for use in Western Blot, Immunohistochemistry and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000, incubate membrane with diluted primary antibody in TBS, 5% milk, 0.1% Tween 20 at 4°C with gentle shaking, overnight
• Immunohistochemistry: 1:50-1:200ELISA (peptide): 1:20,000-1:40,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.